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SARS-CoV-2 infection and vaccination in patients with hairy-cell leukaemia
Enrico Tiacci1, Alessandro Mancini1, Monia Marchetti2
1Istituto di Ematologia e Centro di Ricerche Emato-Oncologiche, Dipartimento di Medicina e Chirurgia, Università e Ospedale di Perugia, Perugia, Italy.
Abstract:
Little is known of the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti-leukaemic treatment, developed COVID-19 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (n = 11 cases) and postvaccination (n = 28) seroconversion consistently developed, except after recent anti-CD20 or venetoclax therapy, correlating with perivaccine B-cell count. Vaccination appeared to protect from severe COVID-19 in 11 patients with breakthrough infection.
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