Utility of dual energy CT in differentiating clot in acute ischemic stroke

Red blood cells (RBC)-poor thrombi in acute ischemic stroke (AIS) are associated with longer recanalization time for mechanical thrombectomy than RBC-rich thrombi. The purpose of the study was to differentiate between RBC-rich and RBC-poor thrombi using dual energy computed tomography (DECT).

This retrospective study was conducted on patients with acute arterial occlusion of anterior circulation who underwent DECT cerebral angiography, followed by mechanical thrombectomy with the pathological diagnosis of thrombi, dividing into RBC-rich and RBC-poor thrombi. The CT attenuation values and thrombus enhancement were measured in non-contrast scans and CTA phases at different energy levels and compared between RBC-rich and RBC-poor groups.

Fourteen acute stroke patients were included in the study. There were 7 patients in RBC-rich group and 7 patients in RBC-poor group. The CT attenuation values of RBC-rich thrombi were significantly higher than those of RBC-poor thrombi at energy levels of 40, 50, 60, 70, and 80 KeV, with the most significant difference at 80 KeV (p = 0.032). A cutoff value of 44.1 Hounsfield units (HU) on 80 keV monoenergetic reconstructions was used to distinguish between RBC-rich and RBC-poor thrombi. It achieved an area under the curve (AUC) of 0.878, sensitivity of 85.7%, specificity of 100%, and accuracy of 92.9%. The degree of enhancement was higher in RBC-poor thrombi than in RBC-rich thrombi, without statistically significant difference.

DECT could help differentiate between RBC-rich and RBC-poor thrombi by using CT attenuation values in non-contrast phase at lower energy levels (40-80 KeV).