Related Experiment Video
Updated: Aug 16, 2025

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
Quantitative and qualitative analyses of metal ions in food and water by using a multicolor sensor array and
Lijuan Huang1, Zinan Zhang1, Huanchun Xing1
1State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China. huanglijuanlmm@sina.com.
Abstract:
Rapid and accurate detection of toxic metal ions is the key to combating food contamination and environmental pollution. In sensor arrays, gold nanoparticles play a crucial role in monitoring metal ions based on surface plasmon resonance. However, identifying metal ions with unknown concentrations in a complex system through this assay is difficult because of its monotonous color change and weak anti-interference ability. To overcome these limitations, a sensitive, flexible, low-cost, and multicolor sensor array was designed herein. The applicability of the sensor array for the qualitative and quantitative analyses of metal ions in food and water was also verified. The developed sensor array could classify 14 metal ions (Cu2+, Fe2+, Fe3+, Mn2+, Ni2+, Zn2+, Cd2+, Cr3+, Co2+, Ba2+, K+, Tl+, Pb2+, and Hg2+) of unknown concentration with an accuracy of 100%. In addition, partial least squares models were established to quantify Tl+, Pb2+, and Hg2+ in water and rice samples, with square correlation coefficients (R2) of 0.9991, 0.9742, and 0.9731, respectively. This method can be used for accurate quantitative and qualitative analyses of heavy metal ions in water and food.
Related Concept Videos
Qualitative Analysis
For instance, group IV...
Complexometric Titration: Overview
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
Complexometric Titration: Ligands
Quantitative Analysis
In quantitative analysis, two key measurements are made: the sample quantity and a property proportional to the amount of the analyte (the substance being analyzed). This forms the basis of the...
High-Performance Liquid Chromatography: Types of Detectors

