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Targeting mTOR Signaling by Dietary Polysaccharides in Cancer Prevention: Advances and Challenges

Mengyuan Li1,2, Zuomin Hu1, Tianyi Guo1

  • 1Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China.

Journal of Agricultural and Food Chemistry
|December 21, 2022
PubMed

Insights

Dietary polysaccharides show promise in cancer treatment by regulating the mammalian target of rapamycin (mTOR) pathway. This review summarizes how these natural compounds impact cancer, offering insights for future research and therapies.

Area of Science:

  • Oncology
  • Natural Products Chemistry
  • Molecular Biology

Background:

  • Cancer poses a significant public health challenge, with conventional treatments often causing severe side effects.
  • Natural products are gaining attention for their potential therapeutic benefits and lower toxicity.
  • Dietary polysaccharides have demonstrated anticancer potential, but their underlying molecular mechanisms require further elucidation.

Purpose of the Study:

  • To systematically review the progress in targeting the mammalian target of rapamycin (mTOR) signaling pathway by dietary polysaccharides in cancer prevention.
  • To elucidate the molecular mechanisms through which dietary polysaccharides exert their anticancer effects via mTOR regulation.
  • To provide a comprehensive reference for researchers investigating the role of polysaccharides in cancer therapy.

Main Methods:

  • Literature review of recent studies on dietary polysaccharides and their interaction with the mTOR pathway in cancer.
  • Systematic summary of research progress and molecular mechanisms.
  • Analysis of the role of mTOR signaling in cell proliferation, growth, and tumor metabolism in relation to polysaccharide intervention.

Main Results:

  • Dietary polysaccharides play a vital role in cancer prevention and treatment.
  • The mammalian target of rapamycin (mTOR) pathway is a key target for antitumor therapies.
  • Polysaccharides regulate tumor metabolism and cell proliferation by modulating the mTOR pathway.

Conclusions:

  • Understanding the molecular mechanisms of polysaccharide action on the mTOR pathway is crucial for advancing cancer therapy.
  • Dietary polysaccharides represent a promising avenue for novel anticancer strategies.
  • This review provides valuable insights for future research in the field of natural products and cancer treatment.
Keywords:
cancerdietary polysaccharidesmTORsignaling pathway

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