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Related Concept Videos

Visual Agnosia01:12

Visual Agnosia

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Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
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Related Experiment Video

Updated: Aug 16, 2025

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

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Unilateral Spatial Neglect Recovery Poststroke.

Alexandra Zezinka Durfee1, Argye E Hillis1,2,3

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (A.Z.D., A.E.H.).

Stroke
|December 21, 2022
PubMed
Summary
This summary is machine-generated.

Unilateral spatial neglect (USN) recovery is better understood through neural mechanisms and predictors. Recent trials show improving quality for USN interventions, though more research is needed.

Keywords:
hemispatial neglectrandomized controlled trialrecovery of functionrehabilitationreviewstroke

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Rehabilitation Medicine

Background:

  • Unilateral spatial neglect (USN) is a frequent and debilitating cognitive deficit following stroke.
  • USN is characterized by reduced awareness or response to stimuli on the side of space opposite to the brain lesion.
  • Understanding USN's neural underpinnings and recovery predictors is crucial for effective treatment.

Purpose of the Study:

  • To provide an updated review of neural mechanisms and recovery predictors for USN.
  • To conduct a rapid review of recent randomized controlled trials (RCTs) for USN interventions.
  • To assess the quality and effectiveness of current USN treatments.

Main Methods:

  • Narrative review of studies on USN neural mechanisms and recovery.
  • Rapid review of RCTs for USN interventions (pharmacological and non-pharmacological) from the last 5 years.
  • Contextualization of RCTs within existing systematic reviews and meta-analyses.

Main Results:

  • Evidence for neural mechanisms and predictors of USN recovery is growing.
  • The quality of recent RCTs for USN treatment is higher than previously reported.
  • Challenges remain in generalizability due to small, heterogeneous samples and incomplete demographic reporting.

Conclusions:

  • Accumulating evidence strengthens the understanding of USN neural recovery and intervention effectiveness.
  • Future research should focus on patient-specific factors influencing treatment response.
  • Addressing methodological weaknesses in RCTs is essential for advancing USN rehabilitation.