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Identifying potential cross-talk signatures for the occurrence of atherosclerosis in diabetic erectile dysfunction

Penghui Yuan1,2, Taotao Sun2, Zhengyang Han3

  • 1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Andrology
|December 21, 2022
PubMed
Abstract

Insights

This study identifies key genes (HBEGF, LOX, NQO1, VLDLR) involved in atherosclerosis in diabetes-related erectile dysfunction. These findings may help manage cardiovascular risks in affected patients.

Area of Science:

  • Cardiovascular Research
  • Genetics and Genomics
  • Endocrinology

Background:

  • Erectile dysfunction and atherosclerosis are common cardiovascular complications.
  • Mechanisms linking erectile dysfunction and atherosclerosis require further elucidation.

Purpose of the Study:

  • To investigate pathological mechanisms and genetic alterations in atherosclerosis within diabetes mellitus-related erectile dysfunction.
  • To identify potential biomarkers for clinical management.

Main Methods:

  • Transcriptome data analysis of diabetes mellitus-related erectile dysfunction and atherosclerosis gene sets.
  • Functional enrichment, immune infiltration, and protein-protein interaction network analyses.
  • Multi-omics validation including diabetic plaques and endothelial cells.

Main Results:

  • Identified 202 significant atherosclerosis-related genes (100 upregulated, 102 downregulated) linked to inflammation and oxidative stress.
  • Discovered differential immune cell expression (immature dendritic cells, monocytes).
  • Identified HBEGF, LOX, NQO1, and VLDLR as key hub genes through multi-omics validation.

Conclusions:

  • Explored atherosclerosis-related genetic changes and pathways in diabetes mellitus-related erectile dysfunction.
  • HBEGF, LOX, NQO1, and VLDLR are proposed as potential biomarkers.
  • These biomarkers may aid in managing atherosclerosis and cardiovascular risks in diabetic patients.
Keywords:
atherosclerosisbioinformaticsbiomarkersdiabeteserectile dysfunction

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