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Testosterone therapy in diabetes and pre-diabetes
Giovanni Corona1, Walter Vena2, Alessandro Pizzocaro2
1Medical Department, Endocrinology Unit, Azienda Usl, Maggiore-Bellaria Hospital, Bologna, Italy.
Andrology
|December 21, 2022
Summary
Men with pre-diabetes or type 2 diabetes often have low testosterone. Testosterone replacement therapy can improve body composition and insulin resistance in these patients, but its effects on weight and lipids are less clear.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Men's Health
Background:
- Type 2 diabetes mellitus (T2DM) and pre-diabetes are linked to lower testosterone levels.
- The efficacy of testosterone replacement therapy (TRT) in these patient groups remains debated.
Conclusions:
- Lifestyle modifications and TRT may benefit symptomatic hypogonadal men by improving metabolic profiles and motivating physical activity.
- Further research is needed to determine if these interventions can prevent T2DM progression from pre-diabetic states.
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