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Published on: August 1, 2018
Uncovering the molecular subtypes of triple-negative breast cancer with a noninvasive radiomic methodology
Guan-Hua Su1, Yi Xiao1, Yi-Zhou Jiang1
1Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Abstract:
In this Backstory, we illustrate how a recent work from our multidisciplinary collaborative group identifies molecular subtypes of triple-negative breast cancer with a noninvasive radiomic pipeline. These findings appeared in the July 2022 issue of Cell Reports Medicine (https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00230-0).
Insights
Researchers identified molecular subtypes of triple-negative breast cancer using a noninvasive radiomic pipeline. This approach offers new insights into breast cancer classification and treatment strategies.
Area of Science:
- Oncology
- Radiology
- Genomics
Background:
- Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies.
- Accurate molecular subtyping is crucial for developing effective treatment strategies.
- Current subtyping methods often require invasive procedures.
Purpose of the Study:
- To identify molecular subtypes of triple-negative breast cancer (TNBC).
- To develop a noninvasive pipeline for molecular subtyping using radiomics.
- To correlate radiomic features with specific molecular TNBC subtypes.
Main Methods:
- Utilized a multidisciplinary collaborative approach.
- Applied a noninvasive radiomic pipeline to analyze breast cancer imaging data.
- Integrated radiomic data with molecular profiling information.
Main Results:
- Successfully identified distinct molecular subtypes within TNBC.
- Demonstrated the feasibility of using radiomics for noninvasive molecular classification.
- Established correlations between specific radiomic signatures and TNBC subtypes.
Conclusions:
- Radiomics offers a promising noninvasive tool for molecular subtyping of TNBC.
- This approach can aid in personalized treatment strategies for TNBC patients.
- Further validation of the radiomic pipeline is warranted for clinical application.
