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Updated: Aug 16, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
Immune mechanisms in fibrotic pulmonary sarcoidosis
Praveen Weeratunga1,2, David R Moller3, Ling-Pei Ho4,2
1Oxford Sarcoidosis Clinic, Oxford Interstitial Lung Disease Service, Oxford, UK.
Abstract:
Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily mapped out over the past few decades. Despite this, the underpinning mechanisms for progressive fibrotic sarcoidosis is an almost uncharted area. Consequently, there has been little change in the clinical management of fibrotic sarcoidosis over the decades and an unfocused search for new therapeutics. In this review, we provide a comprehensive examination of the relevant immune findings in fibrotic and/or progressive pulmonary sarcoidosis and propose a unifying mechanism for the pathobiology of fibrosis in sarcoidosis.
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