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Updated: Aug 16, 2025
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Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
1.2K
Pain and Analgesic Related Insomnia
Jana Mlíchová1, Zoltán Paluch2, Ondřej Šimandl1
1Institute of Pharmacology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Summary
Opioids and other analgesics can negatively impact sleep quality. This review highlights the significant adverse effects of these pain medications on patient sleep patterns.
Area of Science:
- Pharmacology
- Sleep Medicine
- Pain Management
Background:
- Sleep disturbances are common in patients with chronic pain.
- Various medications are used to manage pain, but their effects on sleep are not always well-understood.
Purpose of the Study:
- To review the effects of different classes of analgesics on sleep quality.
- To identify which analgesic medications have the most significant impact on sleep.
Main Methods:
- A systematic literature search was conducted in PubMed and the Cochrane Library from 2000-2020.
- Studies were included if they analyzed the effects of analgesics (opioids, NSAIDs, acetaminophen, adjuvant analgesics) on sleep.
- Data extraction and risk of bias assessment were performed by two independent reviewers.
Main Results:
- 37 studies met the inclusion criteria.
- Opioids were analyzed in 15 studies, nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen in 6, and adjuvant analgesics in 16.
- Opioids demonstrated the most substantial adverse effects on sleep quality.
Conclusions:
- Analgesic medications, particularly opioids, can adversely affect sleep quality.
- Healthcare providers should consider the impact of analgesics on sleep when managing patients with pain.
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