Related Experiment Video
Updated: Aug 16, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
T cell-independent abscopal responses to radiotherapy
Emma Guilbaud1, Takahiro Yamazaki1, Lorenzo Galluzzi2
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Abstract:
When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an 'abscopal' response independent of CD8+ T cells.
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