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Circ_0000284: A risk factor and potential biomarker for prehypertension and hypertension

Mingjun Chen1, Yingying Cai1,2, Jianhui Guo1

  • 1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|December 21, 2022
PubMed

Insights

Circular RNA (circRNA) circ_0000284 is upregulated in hypertension and may serve as an early diagnostic biomarker. This finding offers new insights into hypertension

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • The role of circular RNAs (circRNAs) in disease development is recognized, yet their specific involvement in prehypertension and hypertension remains largely unexplored.
  • Understanding the molecular mechanisms underlying hypertension is crucial for developing effective diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the potential role of circ_0000284 in the molecular regulation of prehypertension and hypertension.
  • To assess the diagnostic value of circ_0000284 in identifying individuals with prehypertension and hypertension.

Main Methods:

  • Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to measure circ_0000284 expression in 300 subjects (100 normal, 100 prehypertension, 100 hypertension).
  • Multivariate logistic regression models, ROC curve analysis, and Spearman correlation were employed to evaluate diagnostic accuracy and clinical correlations.

Main Results:

  • Circ_0000284 expression was significantly upregulated in the prehypertension and hypertension groups compared to the normal blood pressure group, with a notable increasing trend during hypertension progression (P < 0.05).
  • ROC analysis indicated a high diagnostic ability for circ_0000284 in hypertension (AUC = 0.812) and a potential for early diagnosis of prehypertension (AUC = 0.628).
  • Spearman correlation revealed a positive correlation between circ_0000284 expression and serum sodium (Na) and creatine kinase-MB (CKMB) levels.

Conclusions:

  • Upregulated circ_0000284 is identified as an independent risk factor for prehypertension and hypertension.
  • Circ_0000284 shows promise as a biomarker for the early diagnosis of hypertension and for distinguishing intermediate stages of its development.
  • The study provides novel insights into the association between circ_0000284 and cardiac injury during hypertension progression.

Keywords:
BiomarkerCircRNACirc_0000284HypertensionPrehypertension

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