Hippocampus and neocortex send and receive predictive information
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Updated: Aug 16, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
1Vermont Center on Behavior and Health, Departments of Psychological Science and Psychiatry, University of Vermont, 2 Colchester Avenue, Room 106, Burlington, VT, 05405, USA. eric.thrailkill@uvm.edu.
Abstract:
A recent paper published in Nature by Yadav and colleagues (Nature 608 (7921): 153-160, 2022) illustrates a fundamental aspect on how different brain areas participate in memory storage and retrieval. After identifying neuron activity in the hippocampus CA1 region specific to multi-modal stimuli that predicted appetitive and aversive unconditioned stimuli (conjunctive stimulus encoding), the authors showed that neurons located in the anterior cingulate cortex dynamically encode the discrete sensory features of the outcome-predictive stimuli during training, and these highly specific feature-based projections can excite or inhibit conjunctive-coding neurons in the hippocampus during retrieval.
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