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Updated: Aug 16, 2025
Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
Published on: December 29, 2023
Tissue factor as a new target for tumor therapy-killing two birds with one stone: a narrative review
Xiaoying Li1, Dan Cao2, Xiufeng Zheng1
1Gastric Cancer Center/Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Background And Objective:
Cancer is an important disease and can occur anywhere in the body. It is caused by uncontrolled cell growth that spreads to other body parts. This study extensively investigated the transmembrane receptor tissue factor (TF), which is the key motivator of the clotting cascade and plays an essential role in cancer-associated coagulation. TF is considered to be aberrantly expressed in various tumors and appears to promote tumor angiogenesis and metastasis. Therefore, this study was performed to explain the pathological characteristics of TF expression and to discuss future cancer therapies that target TF.
Methods:
We extensively reviewed the literature on TF published in PubMed, and discussed the effect of TF on tumor progression and TF-targeted therapeutics.
Key Content And Findings:
This review aimed to uncover how TFs contribute to tumor progression and cancer-associated thrombosis and summarize TF-based targeted therapy. Multiple functions and mechanisms of the TF in cancer-associated thrombosis and tumor progression were discussed.
Conclusions:
The current literature has confirmed that the TF is involved in the hypercoagulable state of tumors and promotes malignant tumors through coagulation-dependent or non-coagulation-dependent pathways. TF-dependent signaling is also involved in divergent cancer progression. Thus, TF-targeted therapeutics could have broad clinical applicability for the treatment of tumors.
Insights
Tissue factor (TF) drives cancer-associated coagulation and tumor progression. Targeting TF offers promising therapeutic strategies for various cancers.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Cancer involves uncontrolled cell growth and metastasis.
- Tissue factor (TF) is crucial in cancer-associated coagulation.
- Aberrant TF expression promotes tumor angiogenesis and metastasis.
Purpose of the Study:
- Investigate pathological characteristics of TF expression in cancer.
- Discuss TF's role in tumor progression and metastasis.
- Explore TF-targeted cancer therapies.
Main Methods:
- Extensive literature review of TF research.
- Analysis of TF's impact on tumor progression.
- Summary of TF-targeted therapeutic approaches.
Main Results:
- TF is implicated in tumor hypercoagulability.
- TF promotes malignant tumors via coagulation-dependent and independent pathways.
- TF-dependent signaling contributes to cancer progression.
Conclusions:
- TF plays a significant role in cancer-associated thrombosis and tumor progression.
- TF-targeted therapeutics demonstrate broad clinical applicability for cancer treatment.
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