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Assessing the causality between thyroid and breast neoplasms: A bidirectional Mendelian randomization study.

Zhenqi Li1, Lu Xia1, Xiangzhi Li2

  • 1School of Clinical Medicine, Dali University, Dali, China.

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|December 22, 2022
PubMed
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This study found a significant causal link between breast neoplasms and thyroid neoplasms. Enhanced screening for breast cancer in thyroid cancer patients and thyroid cancer in breast cancer patients is recommended.

Keywords:
Mendelian randomization analysisbreast neoplasmsdatabasegeneticsthyroid neoplasms

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Area of Science:

  • Genetics
  • Oncology
  • Epidemiology

Background:

  • The relationship between thyroid neoplasms (TN) and breast neoplasms (BN) requires further investigation.
  • Understanding the genetic interplay between TN and BN is crucial for risk assessment and management.

Purpose of the Study:

  • To evaluate the bidirectional causal association between thyroid neoplasms and breast neoplasms.
  • To leverage genetic data from large consortia (DKFZ and BCAC) for robust analysis.

Main Methods:

  • Utilized a bidirectional Mendelian randomization (MR) approach.
  • Employed multiple statistical methods including MR Egger, weighted median, and inverse variance weighted (IVW) models.
  • Analyzed single nucleotide polymorphism (SNP) data from genome-wide association studies (GWAS).

Main Results:

  • A modest reverse causal relationship was observed between thyroid neoplasms and breast neoplasms.
  • A significant positive causal relationship was identified from breast neoplasms to thyroid neoplasms.

Conclusions:

  • Genetic evidence supports an association between breast and thyroid neoplasms.
  • Clinical recommendations include general breast screening for individuals with TN and reinforced TN screening for individuals with BN.
  • Further research into the interaction mechanisms between these malignancies is warranted.