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Milestones in acute GVHD pathophysiology.

Gerard Socie1,2,3, David Michonneau1,2,3

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This review highlights key publications advancing the understanding of acute graft-versus-host disease (GVHD) pathophysiology. It provides a historical perspective on milestone research in GVHD, essential for researchers in the field.

Keywords:
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Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Over 25,000 articles published on graft-versus-host disease (GVHD) in 65 years.
  • Thousands of publications focus on the pathophysiology of acute GVHD.
  • Existing literature presents a challenge in identifying seminal works due to volume and scope.

Purpose of the Study:

  • To provide a historical review of milestone publications in acute GVHD.
  • To identify research that has significantly advanced the understanding of GVHD pathophysiology.
  • To offer a curated perspective on pivotal contributions to the field.

Main Methods:

  • Historical literature review.
  • Identification and synthesis of prominent publications considered milestones in GVHD research.
  • Inclusion of review articles for comprehensive coverage of specific aspects.

Main Results:

  • Identification of key publications that have propelled the field of GVHD research forward.
  • A curated historical perspective on the evolution of knowledge regarding acute GVHD pathophysiology.
  • Acknowledgment of the inherent challenges and potential biases in selecting milestone articles.

Conclusions:

  • The review consolidates critical research, offering a guide to understanding GVHD's historical scientific progression.
  • This historical overview serves as a valuable resource for researchers and clinicians in the field of transplantation.
  • Further exploration of specific aspects through cited reviews is recommended for in-depth knowledge.