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Updated: Aug 16, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
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Protein charge parameters that influence stability and cellular internalization of polyelectrolyte complex micelles

Rachel A Kapelner1, Rachel S Fisher1,2, Shana Elbaum-Garfinkle2,3

  • 1Department of Chemical Engineering, Columbia University New York NY 10027 USA aco2134@columbia.edu +1-212-853-1215.

Chemical Science
|December 22, 2022
PubMed
Summary

Researchers developed polyelectrolyte complex (PEC) micelles for delivering anionic proteins, overcoming challenges like aggregation and poor cellular uptake. These novel protein delivery vehicles show promise for intracellular delivery of therapeutic proteins.

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