Nanocarrier system: An emerging strategy for bioactive peptide delivery

Area of Science:

• Biomaterials Science
• Drug Delivery
• Peptide Therapeutics

Background:

• Bioactive peptides possess superior efficiency, selectivity, and safety compared to synthetic drugs.
• Significant barriers (mucus, enzymes, epithelial) impede bioactive peptide bioavailability and stability.
• Effective delivery systems are crucial for maximizing the potential of bioactive peptides.

Purpose of the Study:

• To comprehensively review versatile nanocarrier systems for bioactive peptide delivery.
• To analyze the structural characteristics, advantages, and disadvantages of various delivery systems.
• To provide a reference for enhancing bioactive peptide utilization.

Main Methods:

• Literature review of nanocarrier systems including liposomes, polymer nanoparticles, polysaccharides, hydrogels, and self-emulsifying systems.
• Analysis of structural properties and delivery performance of each system.
• Evaluation of advantages and disadvantages for bioactive peptide embedding.

Main Results:

• Various nanocarrier systems demonstrate potential for embedding bioactive peptides.
• Liposomes, polymer nanoparticles, polysaccharides, hydrogels, and self-emulsifying systems offer distinct structural and functional properties.
• Each system presents unique advantages and limitations impacting peptide delivery.

Conclusions:

• Nanocarrier systems are essential for overcoming bioavailability and biostability challenges of bioactive peptides.
• Versatile delivery systems offer a promising strategy for the effective application of bioactive peptides.
• Further research into nanocarrier optimization can unlock the full therapeutic and nutritional potential of bioactive peptides.