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Association between Cardio-Ankle Vascular Index and Masked Uncontrolled Hypertension in Hypertensive Patients: A

Ning Wang1,2, Ying Guo1,2, Xueting Li1,3

  • 1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Journal of Healthcare Engineering
|December 22, 2022
PubMed

Insights

Cardio-ankle vascular index (CAVI), a measure of arterial stiffness, is an independent risk factor for masked uncontrolled hypertension (MUCH). High CAVI in hypertensive patients with normal office blood pressure indicates a need for ambulatory BP monitoring to detect MUCH.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Masked uncontrolled hypertension (MUCH), normal office BP with elevated ambulatory BP, is challenging to detect.
  • Arterial stiffness, assessed by cardio-ankle vascular index (CAVI), is a key hypertension risk marker.

Purpose of the Study:

  • To evaluate the association between CAVI and MUCH in hypertensive patients.
  • To determine if CAVI can serve as an early indicator for MUCH.

Main Methods:

  • 155 hypertensive patients underwent office BP and ambulatory BP monitoring.
  • Patients were categorized into controlled hypertension (CH), MUCH, and sustained uncontrolled hypertension (SUCH) groups.
  • CAVI measurements were compared across groups, and logistic regression was used for analysis.

Main Results:

  • Both MUCH and SUCH groups exhibited significantly higher CAVI than the CH group (p=0.017 and p=0.002, respectively).
  • Increased CAVI was independently associated with the presence of MUCH and SUCH (OR 2.046, p=0.005; OR 2.215, p=0.003).
  • No significant difference in CAVI was found between MUCH and SUCH groups.

Conclusions:

  • CAVI is an independent risk factor for MUCH, comparable in importance to sustained uncontrolled hypertension.
  • High CAVI in hypertensive patients with normal office BP warrants further ambulatory BP monitoring for MUCH detection.
  • CAVI shows potential as a noninvasive tool for early identification of patients with MUCH.

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