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Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Immunological Memory01:23

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Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Updated: Aug 16, 2025

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IgE-expressing long-lived plasma cells in persistent sensitization.

Shiqiu Xiong1,2, Yang Jia3, Chuanhe Liu1,2

  • 1Department of Allergy, Center for Asthma Prevention and Lung Function Laboratory, Children's Hospital of Capital Institute of Pediatrics, Beijing, China.

Frontiers in Pediatrics
|December 22, 2022
PubMed
Summary

Persistent allergies are linked to long-lived plasma cells (LLPCs) secreting IgE. This review explores IgE+ LLPC generation, survival factors, and signaling, offering insights into allergy persistence.

Keywords:
B cell receptorIgEclass switch recombinationlong-lived plasma cellsmicroenviromentpersistent sensitization

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Area of Science:

  • Immunology
  • Allergy Research

Background:

  • Persistent allergies significantly impact patient quality of life and incur economic costs.
  • Long-lived plasma cells (LLPCs) secreting immunoglobulin E (IgE) are implicated in chronic allergic conditions.
  • The specific characteristics and survival mechanisms of IgE-producing LLPCs remain incompletely understood.

Purpose of the Study:

  • To review the current understanding of IgE-producing plasma cell generation.
  • To discuss factors within the microenvironment that promote the survival of IgE+ LLPCs.
  • To explore the unique signaling pathways of the IgE B-cell receptor (BCR) in LLPC survival.

Main Methods:

  • Literature review of immunological studies on plasma cells and IgE.
  • Analysis of research on microenvironmental prosurvival factors.
  • Examination of studies detailing IgE-BCR signaling pathways.

Main Results:

  • The review synthesizes information on the differentiation pathways leading to IgE+ PCs.
  • Key microenvironmental factors supporting LLPC longevity are identified.
  • Unique aspects of IgE-BCR signaling contributing to LLPC persistence are highlighted.

Conclusions:

  • Understanding IgE+ LLPC generation and survival is crucial for managing persistent allergies.
  • Targeting IgE+ LLPC survival mechanisms may offer novel therapeutic strategies for allergic diseases.
  • Further research into IgE-BCR signaling could reveal new avenues for allergy treatment.