Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroxine transport in choroid plexus.

P W Dickson1, A R Aldred, J G Menting

  • 1Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia.

The Journal of Biological Chemistry
|October 15, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative cytology research; the rhythmic growth of the nucleus in the renal channels of Leptodactylus; conditions on somatic polyploidism.

Revista brasileira de biologia·2014
Same author

The Archaebacterium Thermofilum pendens Represents, a Novel Genus of the Thermophilic, Anaerobic Sulfur Respiring Thermoproteales.

Systematic and applied microbiology·2012
Same author

Typha capensis (Rohrb.)N.E.Br. (bulrush) extract scavenges free radicals, inhibits collagenase activity and affects human sperm motility and mitochondrial membrane potential in vitro: a pilot study.

Andrologia·2011
Same author

Chronological practice of current preventive vaccinations.

Concours medical·2010
Same author

Has the treatment of epidemic polio made progress since the beginning of the century?

Concours medical·2010
Same author

The new regulations for the premarital medical certificate.

La Presse medicale·2010

The choroid plexus transports thyroid hormones into the brain. Transthyretin, synthesized by the choroid plexus, aids in thyroxine transport from blood to cerebrospinal fluid.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cell Biology

Background:

  • The choroid plexus is a key tissue for regulating the brain's internal environment.
  • Transthyretin (TTR) is synthesized and secreted by the choroid plexus, suggesting a role in thyroid hormone transport.
  • Thyroid hormones are crucial for brain development and function.

Purpose of the Study:

  • To investigate the role of the choroid plexus in thyroid hormone transport between the body and the brain.
  • To elucidate the mechanism of thyroxine and triiodothyronine transport across the blood-brain barrier.

Main Methods:

  • In vitro incubation of rat choroid plexus with thyroid hormones.
  • Liposome-based assays to determine hormone partitioning.
  • In vivo studies using 125I-labeled thyroid hormones in rats.

Related Experiment Videos

Main Results:

  • Choroid plexus accumulated thyroid hormones in vitro via a non-saturable process.
  • Increased transthyretin concentration reduced thyroid hormone accumulation in vitro.
  • In vivo, choroid plexus and brain accumulated 125I-thyroxine, but not 125I-triiodothyronine.
  • 125I-thyroxine accumulation in choroid plexus preceded brain accumulation.

Conclusions:

  • The choroid plexus plays a significant role in regulating thyroid hormone levels in the brain.
  • Thyroxine transport into the cerebrospinal fluid involves partitioning into the choroid plexus and binding to transthyretin.
  • Transthyretin facilitates the transport of thyroxine from the bloodstream to the brain.