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Risk factors for long-term decline in post-operative pulmonary function after lung resection
Norifumi Tsubokawa1, Takeshi Mimura1, Kazuki Tadokoro1
1Department of General Thoracic Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Japanese Journal of Clinical Oncology
|December 22, 2022
Summary
Long-term decline in vital capacity after lung cancer surgery, influenced by resected segments and complications, negatively impacts survival. Monitoring pulmonary function is crucial for patient outcomes.
Area of Science:
- Thoracic Surgery
- Pulmonary Medicine
- Oncology
Background:
- Anatomical resection for lung cancer can lead to pulmonary function decline.
- Understanding risk factors and long-term effects is crucial for patient management.
Purpose of the Study:
- To identify risk factors for long-term pulmonary function decline after lung cancer resection.
- To assess the impact of this decline on patient survival.
Main Methods:
- Retrospective analysis of 489 lung cancer patients undergoing anatomical resection (2010-2020).
- Pulmonary function tests (forced expiratory volume in 1 second, vital capacity) assessed preoperatively and up to 12 months post-surgery.
- Risk factors identified using multivariable logistic and Cox regression analyses.
Main Results:
- Pulmonary function decreased most in the first month, with gradual recovery.
- Number of resected segments and post-operative complications were risk factors for vital capacity decline.
- Decreased vital capacity at 12 months was significantly associated with reduced overall survival.
Conclusions:
- Long-term vital capacity reduction after lung cancer surgery is linked to the number of resected segments and complications.
- This decline adversely affects overall survival.
- Vital capacity monitoring post-surgery is important for predicting patient outcomes.
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