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Plasmonic Array at the Liquid-Liquid Interface: A Dual-Mode Optical Sensing Platform for Multianalytes.

Minggang Zhao1, Xiaoming Wang1, Zhensen Liang1

  • 1Department of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China.

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This study introduces a novel dual-mode optical sensing platform using gold nanoparticles (AuNPs) for highly sensitive multianalyte detection. The innovative method enhances nanoparticle diffusion and condensation for improved trace detection sensitivity and repeatability.

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Area of Science:

  • Nanotechnology
  • Optical Sensing
  • Surface Chemistry

Background:

  • Analyte-triggered nanoparticle (NP) assemblies are used in optical sensors.
  • Slow NP diffusion and low analyte concentrations limit sensitivity and repeatability in trace detection.

Purpose of the Study:

  • To develop a dual-mode optical sensing platform for multianalyte detection.
  • To overcome limitations of NP diffusion dynamics and analyte concentration in trace detection.

Main Methods:

  • Functionalized gold NPs with specific ligands.
  • Constructed a dual-mode optical sensing platform at the liquid-liquid interface.
  • Utilized emulsification to boost NP diffusion kinetics and condense NPs into a plasmonic array.

Main Results:

  • The plasmonic NP array at the interface generates reflectance and surface-enhanced Raman scattering changes.
  • Achieved limits of detection for cysteine at 193 ± 2 pM and glucose at 297 ± 12 pM.
  • Demonstrated enhanced sensitivity and repeatability for trace analyte detection.

Conclusions:

  • The developed dual-mode sensing platform offers improved sensitivity and repeatability for multianalyte detection.
  • The liquid-liquid interface condensation strategy effectively overcomes traditional NP assembly limitations.
  • This approach holds promise for advanced optical sensing applications.