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Effects of Major Depressive Disorder on Monocytes, High-Density Lipoprotein (HDL) and Monocyte to HDL Ratio: A
1Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, 21280, Turkey, betuluyar@hotmail.com.
Insights
Major Depressive Disorder (MDD) is linked to higher monocyte counts and Monocyte to HDL Ratios (MHR), with lower High-Density Lipoprotein (HDL) levels. Increased depression severity correlates with higher MHR, suggesting MHR as an inflammation marker in MDD.
Area of Science:
- Biomedical Science
- Clinical Research
- Psychiatry
Background:
- Major Depressive Disorder (MDD) is a prevalent mental health condition associated with systemic inflammation.
- Inflammatory markers are increasingly recognized as potential contributors to and indicators of MDD.
- Understanding the relationship between specific hematological parameters and MDD is crucial for diagnostic and prognostic insights.
Purpose of the Study:
- To investigate the association between Major Depressive Disorder (MDD) and key inflammatory markers: monocyte count, High-Density Lipoprotein (HDL) levels, and the Monocyte to HDL Ratio (MHR).
- To explore correlations between these markers, depression severity, and treatment status in MDD patients.
Main Methods:
- A retrospective case-control study comparing 120 MDD patients with 124 healthy controls.
- Data collection included demographic information, depression severity scales (CGI, HDRS), and laboratory tests for lipid profiles and complete blood counts.
- Statistical analysis employed Kruskal-Wallis, Mann-Whitney U, and independent-samples t-tests.
Main Results:
- MDD patients exhibited significantly higher monocyte counts and MHR, and lower HDL levels compared to healthy controls.
- Higher MHR and monocyte counts, along with lower HDL, were observed in treatment-naïve MDD patients versus those who received treatment.
- A positive correlation was found between increasing depression severity and elevated MHR levels.
Conclusions:
- This study is the first to demonstrate a significantly higher MHR in MDD patients compared to healthy individuals.
- The Monocyte to HDL Ratio (MHR) shows a positive correlation with depression severity.
- MHR presents a potential as a simple, practical, and cost-effective biomarker for inflammation in Major Depressive Disorder.
Objective:
In this study, we investigated the effects of Major Depressive Disorder (MDD) on monocyte counts, High-Density Lipoprotein (HDL) levels, and Monocyte to HDL ratios (MHR) among inflammatory markers.
Method:
This is a retrospective case-control study. The case group of our study included 120 major depressive patients. The control group included 124 healthy individuals. The data were collected using a Personal Information Form, the Clinical Global Impression Scale, and the Hamilton Depression Rating Scale. The lipid profiles and complete blood count parameters of the case and control groups were tested and compared. The collected data were analyzed using the Kruskal-Wallis test, Mann-Whitney U test and independent-samples t-test.
Results:
A significant increase in the monocyte and MHR values and a decrease in the HDL values of the case group were observed with older ages (p<0.01). In the case group, the MHR and monocyte count values were higher, and the HDL levels were lower in the MDD patients who had never received treatment in comparison to those who had received treatment. As the severity of depression increased, MHR levels also increased.
Conclusion:
Our study is the first study to show that MHR is significantly higher in MDD patients than healthy controls. It was also shown that depression severity and MHR are positively correlated. Consequently, MHR might be a simple, practical, and low-cost parameter which shows inflammation in MDD patients.
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