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Automated High-throughput Behavioral Analyses in Zebrafish Larvae
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Zebrafish - The Neurobehavioural Model in Trend.

R Mrinalini1, T Tamilanban1, V Naveen Kumar1

  • 1Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur 603 203, India.

Neuroscience
|December 22, 2022
PubMed
Summary

Zebrafish (Danio rerio) are a valuable model for neurobehavioral research due to genetic similarity and ease of use. This review details their application in drug screening and neuroscience, highlighting their advantages.

Keywords:
Danio rerioembryologynervous system diseaseszebrafish

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Neurobehavioral disorders present significant diagnostic and etiological challenges.
  • Developing novel pharmacological interventions requires robust experimental models.
  • Zebrafish (Danio rerio) have emerged as a prominent model organism in neuroscience research.

Purpose of the Study:

  • To review the advancements and utility of zebrafish as an experimental model in neurobehavioral studies.
  • To provide a comprehensive overview of zebrafish applications in screening neuroactive drugs.
  • To discuss the tools, techniques, and methodologies supporting zebrafish research in neuroscience.

Main Methods:

  • Literature review of zebrafish applications in neurobehavioral research.
  • Compilation and tabulation of assays and responses used in neuroactive drug screening.
  • Discussion of breeding, maintenance, and available strains of zebrafish.

Main Results:

  • Zebrafish offer significant advantages as a model organism, including genetic homology with humans and ease of manipulation.
  • Various assays and tests have been successfully employed to screen neuroactive compounds using zebrafish.
  • Detailed information on husbandry, available strains, and research tools facilitates their use.

Conclusions:

  • Zebrafish are a highly advantageous and versatile model for studying neurobehavioral disorders and for drug discovery.
  • Standardizing model organisms like zebrafish minimizes inter-species variations, enhancing result consistency.
  • The review supports the continued and expanded use of zebrafish in neuroscience research.