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Updated: Aug 16, 2025

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Published on: February 3, 2023
Citric acid esterified Glutinous Assam bora rice starch enhances disintegration and dissolution efficiency of model
Pratap Kalita1, Abdul Baquee Ahmed2, Saikat Sen3
1Pratiksha Institute of Pharmaceutical Sciences, Guwahati, Assam 781026, India; Assam Science and Technology University, Guwahati, Assam 781013, India.
Abstract:
The current work was designed to study the starch's physicochemical attributes, tablet disintegration and dissolution efficiency and its derivatives obtained from the glutinous Assam bora rice (G-ABR) variety of Assam, Northeast India. Starch was isolated by a simple protein denaturation method, and a starch derivative was prepared through citric acid modification. G-ABRS and citrated G-ABRS were characterized through FTIR, DSC, XRD and SEM. The rate of consolidation, consolidation index, angle of internal friction, packing rearrangement and cohesive properties were determined to investigate their applications as functional excipients in pharmaceutical industries. G-ABRS and citrated G-ABRS exhibited better packing rearrangement and cohesive properties than standard corn starch. Furthermore, immediate release of API from the tablet compact was observed when the starch concentration increased from 1 to 5 %, indicating facilitation of the tablet compact disintegration. Therefore, G-ABRS and citrated G-ABRS are potentially functional and sustainable materials for pharmaceutical industries.
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