Related Experiment Video
Updated: Aug 16, 2025
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Does an educational video for aneuploidy screening improve informed choice among pregnant women? A randomised
Karen Mei Xian Lim1, Celine Lewis2,3, Hung Chew Wong4
1Department of Obstetrics & Gynaecology, National University Hospital, Singapore, Singapore.
Background:
Poor knowledge and the lack of deliberation have been cited as reasons for women making uninformed choices about aneuploidy screening. Adequate pre-test counselling is of particular importance where non-invasive prenatal screening (NIPS) is being increasingly offered as a primary screening test.
Design:
Women attending the antenatal clinic with a singleton pregnancy below 14 weeks were randomised to receive routine counselling or the intervention-a 16-min educational video on aneuploidy screening before their consult. The primary outcome, rate of informed choice, was assessed using an adapted multidimensional measure of informed choice questionnaire, where informed choice was defined as good knowledge and value-consistent behaviour. Secondary outcomes included informed choice with deliberation, decisional conflict and anxiety.
Results:
Two hundred and eighty-six women were recruited. 69.8% of women in the intervention group made an informed choice compared with 53.6% in the control group (Risk Ratio [RR] 1.30, p = 0.014). A significantly higher number of women in the intervention group had good knowledge compared to controls (81% vs. 60.9%; RR 1.33, p = 0.001). Decisional conflict did not differ between groups, but women in the intervention group had higher anxiety scores (p < 0.001).
Conclusion:
The study intervention was effective in helping women make informed choice. Qualitative studies to determine the reason for increased anxiety are needed.
Trial Registration:
Trial registry: ClinicalTrials.gov; Identifier: NCT05492981.
