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Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

28
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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Nursing Assessment of the Genitourinary System I: Health History01:21

Nursing Assessment of the Genitourinary System I: Health History

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The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

49
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Related Experiment Video

Updated: Aug 16, 2025

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
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Prostatitis As An Initial Presentation For Granulomatosis With Polyangiitis.

Nauman Ismat Butt1, Raheel Younus2, Muhammad Qasim Khan Tareen3

  • 1Department of Medicine & Allied, Azra Naheed Medial College Superior University Lahore.

Journal of Ayub Medical College, Abbottabad : JAMC
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

Granulomatosis with polyangiitis, a rare vasculitis, can initially present as prostatitis. This case highlights the importance of considering GPA in patients with persistent urinary symptoms and negative cultures.

Keywords:
Granulomatosis with PolyangiitisProstatitis; Vasculitis; c-ANCA

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Area of Science:

  • Nephrology
  • Rheumatology
  • Urology

Background:

  • Granulomatosis with polyangiitis (GPA) is a rare pauci-immune small-vessel vasculitis.
  • GPA typically affects individuals aged 45-60 and involves the respiratory tract and kidneys.
  • Prostatitis is an uncommon initial manifestation of GPA.

Observation:

  • A 44-year-old male presented with prolonged dysuria and urinary retention unresponsive to antibiotics and TURP.
  • Prostate biopsy revealed necrotising granulomatous prostatitis with sterile pyuria and hematuria.
  • The patient later developed systemic symptoms including fever, cough, dyspnea, and skin ulcers.

Findings:

  • Chest CT revealed cavitary lesions and pleural effusion.
  • Anti-neutrophil cytoplasmic antibody (c-ANCA) testing was positive.
  • The constellation of symptoms and positive c-ANCA confirmed the diagnosis of GPA.

Implications:

  • This case underscores the importance of considering GPA in the differential diagnosis of granulomatous prostatitis, especially when initial treatments fail.
  • Early recognition of GPA, even with unusual initial presentations like prostatitis, is crucial for timely management and preventing organ damage.
  • The study highlights the diverse clinical spectrum of GPA and the need for a comprehensive diagnostic approach.