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Updated: Aug 16, 2025

Endoscopic Cholesteatoma Surgery
Published on: January 19, 2022
Gorham-Stout syndrome: A chylothorax disease with bony destruction: A case report
Ping-Yang Hong1, Xiao-Bin Zhang1, Hui-Qing Zeng1
1Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University; the Third Clinical Medical College of Fujian Medical University, Fujian, China.
Rationale:
Gorham-Stout syndrome is a sporadic condition characterized by a tumor-like lesion with extensive osteolysis, severe symptoms, and a poor prognosis. Poor prognostic indicators include osteolytic lesions of the spine and pleura effusion.
Patient Concerns:
A 67-year-old Chinese man with five months history of chest tightness presented to our institution with aggravated shortness of breath. Ultrasonography demonstrated hydrothorax on the right side. The patient's imaging studies (computerized tomography [CT] scan, magnetic resonance imaging, and positron emission tomography [PET]/CT) revealed osteolytic lesions (the skull, several spines, several ribs, both shoulder blades, and the pelvis).
Diagnoses:
Gorham-Stout syndrome. (4) Interventions: We advised the patient to follow a low-fat diet. On the patient, we performed a superior vena cava angiography. The injection of zoledronic acid was used to prevent bone loss.
Outcomes:
We found resolution of chylothorax after a low-fat diet, superior vena cava angiography and injection of zoledronic acid.
Lessons:
The possibility of Gorham -Stout syndrome should be ruled out in patients with clinical chylothorax. The relief of chylothorax requires comprehensive treatment.
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