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In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
Published on: April 18, 2025
508
Bioengineering Liver Organoids for Diseases Modelling and Transplantation
Junzhi Li1,2, Jing Chu1, Vincent Chi Hang Lui1
1Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China.
Bioengineering (Basel, Switzerland)
|December 23, 2022
Summary
Liver organoids mimic native tissues, offering clinical potential. Bioengineering advances are creating sophisticated mini-livers with improved cell composition and architecture for disease modeling and applications.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Organoids, 3D cellular structures, partially replicate native tissue physiology and micro-architecture.
- Successful liver organoid development relies on understanding physical cues and biochemical signals.
- Current liver organoids often lack the cellular diversity and precise spatial organization of native livers.
Purpose of the Study:
- To review recent advancements in bioengineered liver organoids.
- To focus on cell sources, growth factors, and engineering approaches for liver organoid construction.
- To highlight the development of liver organoid disease models and their biomedical applications.
Main Methods:
- Review of current literature on liver organoid systems.
- Analysis of stem-cell, biomaterial, and engineering-based approaches.
- Examination of growth factor roles in liver organoid development.
Main Results:
- Organoid development is enhanced by understanding physical and biochemical factors.
- Advanced bioengineering approaches are creating more sophisticated liver organoids.
- Liver organoid disease models are emerging for biomedical applications.
Conclusions:
- Bioengineered liver organoids show promise for mimicking native liver structure and function.
- Further research in cell sourcing and engineering is crucial for developing near-native mini-livers.
- Liver organoids hold significant potential for disease modeling and clinical applications.
