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Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Related Experiment Video

Updated: Aug 16, 2025

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release
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Increasing Cellular Uptake and Permeation of Curcumin Using a Novel Polymer-Surfactant Formulation.

Zhenqi Liu1, Alison B Lansley1, Tu Ngoc Duong2

  • 1Biomaterials and Drug Delivery Research Group, School of Applied Sciences, University of Brighton, Brighton BN2 4GJ, UK.

Biomolecules
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

Novel polymer-surfactant formulations significantly enhanced curcumin solubility and oral drug delivery. Formulation A, with Soluplus® and vitamin E TPGs, showed improved permeation and cellular uptake in Caco-2 cell models.

Keywords:
Caco-2 cellLongvida®Nacumin®Soluplus®aqueous solubilitycell permeabilitycurcumincytotoxicityoral bioavailabilityvitamin E TPGs

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Materials Science

Background:

  • Poor water solubility of therapeutic molecules presents a significant challenge for oral drug delivery.
  • Developing effective oral formulations for poorly soluble drugs is crucial for patient compliance and therapeutic efficacy.

Purpose of the Study:

  • To investigate novel polymer-surfactant formulations (A and B) for enhancing curcumin solubility and permeability.
  • To evaluate the potential of these formulations for improved oral drug delivery of curcumin.

Main Methods:

  • Solubility and physicochemical characterization (FTIR, DSC, XRD) of formulations.
  • Cytotoxicity assessment using MTT and LDH assays.
  • In vitro drug transport and cellular uptake studies using the Caco-2 cell model, calculating apparent permeability coefficients (Papp).

Main Results:

  • Formulation A demonstrated a significant increase in curcumin permeation and cellular uptake compared to other formulations.
  • The study highlighted that Papp (solution) is a more accurate indicator of drug permeation than Papp (suspension).
  • Increased aqueous solubility of curcumin in Formulation A was linked to its enhanced permeation and uptake.

Conclusions:

  • Novel polymer-surfactant formulations, particularly Formulation A, can effectively improve the solubility, permeation, and cellular uptake of poorly water-soluble drugs like curcumin.
  • Formulation A, incorporating Soluplus® and vitamin E TPGs, represents a promising approach for enhancing oral curcumin delivery.
  • The findings support the development of advanced formulations to overcome solubility challenges in drug delivery.