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Gold(III) Complexes Activity against Multidrug-Resistant Bacteria of Veterinary Significance.

Carlos Ratia1, Sara Sueiro1, Raquel G Soengas2

  • 1ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain.

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|December 23, 2022
PubMed
Summary

Gold(III) complexes show promise as novel antibacterial agents against multidrug-resistant bacteria. Combining these gold(III) complexes with colistin may reduce toxicity and enhance effectiveness for veterinary applications.

Keywords:
MDR-bacteriaanimal strainsantibacterialantibiofilmgold(III) complexestoxicity

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Area of Science:

  • Medicinal Chemistry
  • Antimicrobial Resistance
  • Veterinary Medicine

Background:

  • Multidrug-resistant bacteria pose a significant global health threat.
  • There is an urgent need for novel antimicrobial strategies due to a limited antibiotic pipeline.
  • Gold(III) complexes (G3Cs) have emerged as potential antibacterial agents.

Purpose of the Study:

  • To evaluate the antimicrobial and antibiofilm activity of G3Cs against veterinary pathogens.
  • To assess the synergistic effects of G3Cs combined with colistin.
  • To determine the in vitro cytotoxicity of G3Cs.

Main Methods:

  • Minimal Inhibitory Concentration (MIC) determination via broth microdilution.
  • Antibiofilm activity assessed using crystal violet staining.
  • Cytotoxicity evaluated on commercial human cell lines.

Main Results:

  • Four and seven G3Cs exhibited activity against Gram-negative and Gram-positive bacteria, respectively.
  • G3Cs demonstrated antibiofilm activity against Gram-negative species.
  • Combinations of G3Cs and colistin showed synergistic effects, reducing concentrations and toxicity.

Conclusions:

  • G3Cs possess significant antimicrobial and antibiofilm properties.
  • Synergistic combinations with colistin offer a promising strategy to combat multidrug-resistant bacteria.
  • G3Cs represent a potential new therapeutic alternative for infections of veterinary origin.