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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections.

Darragh G Kennedy1,2, Aoife M O'Mahony1, Eamonn P Culligan3

  • 1School of Pharmacy, University College Cork, T12 K8AF Cork, Ireland.

Antibiotics (Basel, Switzerland)
|December 23, 2022
PubMed
Summary

Orthopaedic implant infections are a major challenge, often caused by biofilms. New device technologies aim to prevent these infections by controlling antimicrobial release and surface interactions.

Keywords:
antimicrobialbiofilmbioinspireddrug deliveryimplant coatinginfectionmedical devicenanotechnologyorthopaedic implantspolymer

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Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Orthopaedic Surgery

Background:

  • Orthopaedic implants are vital for restoring function after injury or disease.
  • Implant-associated infections pose significant clinical and economic burdens.
  • Biofilm formation on implants complicates treatment and increases morbidity.

Purpose of the Study:

  • To review the pathogenesis of orthopaedic implant infections.
  • To highlight challenges posed by biofilm formation.
  • To explore advancements in next-generation orthopaedic devices for infection mitigation.

Main Methods:

  • Review of current literature on orthopaedic implant infections.
  • Analysis of biofilm formation mechanisms and treatment implications.
  • Examination of novel technologies for antimicrobial delivery and surface modification.

Main Results:

  • Biofilm formation is a key challenge in orthopaedic implant infections.
  • Next-generation devices focus on controlled antimicrobial release and surface properties.
  • Surface modifications aim to reduce bacterial colonization and biofilm development.

Conclusions:

  • Preventing orthopaedic implant infections requires innovative device design.
  • Controlling bio-interfacial interactions is crucial for reducing infection risk.
  • Future orthopaedic devices will incorporate advanced strategies to combat infection.