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Updated: Aug 16, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
Gnetin C Intercepts MTA1-Associated Neoplastic Progression in Prostate Cancer
Prashanth Parupathi1, Gisella Campanelli1, Rabab Al Deabel2
1Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA.
Gnetin C, a compound from the melinjo plant, shows promise for prostate cancer prevention. It effectively delays tumor progression in a high-risk mouse model without causing toxicity.
Area of Science:
- Nutritional chemoprevention
- Prostate cancer research
- Phytochemicals and cancer
Background:
- Prostate cancer chemoprevention is a key area of research.
- Gnetin C, a resveratrol dimer from Gnetum gnemon, exhibits potent biological properties.
- Metastasis-associated protein 1 (MTA1) overexpression drives prostate cancer progression.
Purpose of the Study:
- To evaluate the chemopreventive effects of Gnetin C in a high-risk prostate cancer mouse model.
- To investigate the impact of Gnetin C on MTA1-promoted tumor progression and related molecular markers.
Main Methods:
- A transgenic mouse model (R26; Pten; Pb-Cre) overexpressing MTA1 was used.
- Mice were fed diets supplemented with pterostilbene, high-dose Gnetin C, or low-dose Gnetin C.
- Prostate tissues were analyzed for histopathology, proliferation, angiogenesis, and molecular markers (MTA1, PTEN). Serum cytokine levels (IL-2) were measured.
Main Results:
- Gnetin C supplementation significantly delayed premalignant lesion progression compared to controls.
- Reduced prostatic intraepithelial neoplasia (PIN) foci, proliferation, and angiogenesis were observed in Gnetin C-fed mice.
- Decreased MTA1 levels, increased phosphatase and tensin homolog (PTEN) expression trend, and reduced serum IL-2 were noted with Gnetin C.
Conclusions:
- Gnetin C effectively inhibits MTA1-driven tumor progression in a high-risk premalignant prostate cancer model.
- Gnetin C demonstrates potential as a novel nutritional strategy for prostate cancer chemoprevention.
- No visible toxicity was observed, supporting its safety profile for dietary intervention.
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