Related Experiment Video

Updated: Aug 16, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K

Cardiovascular Magnetic Resonance Imaging-Based Right Atrial Strain Analysis of Cardiac Amyloidosis

Jan Eckstein1, Vanessa Sciacca2, Hermann Körperich1

  • 1Institute for Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine Westphalia, University of Bochum, 32545 Bad Oeynhausen, Germany.

Biomedicines
|December 23, 2022
PubMed

Insights

Magnetic resonance imaging (MRI) can quantify right atrial strain (RAS) and strain rate (RASR) to help differentiate cardiac amyloidosis (CA) from hypertrophic cardiomyopathy (HCM). These MRI measures show impaired right atrial function in CA patients, aiding diagnosis.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiac Physiology

Background:

  • Cardiac amyloidosis (CA) presents as a hypertrophic phenotype, mimicking hypertrophic cardiomyopathy (HCM), which complicates diagnosis and delays treatment.
  • The diagnostic utility of magnetic resonance imaging (MRI) in quantifying right atrial strain (RAS) and strain rate (RASR) for differentiating CA and HCM is not well-established.

Purpose of the Study:

  • To assess diagnostic differences in longitudinal RAS and RASR between CA, HCM, and control subjects (CTRL).
  • To investigate the impact of atrial fibrillation (AF) on right atrial function in CA patients.
  • To evaluate the potential for diagnostic overlap using RAS and RASR in tricuspid regurgitation (TR) patients.

Main Methods:

  • Quantification of RAS and RASR using MRI feature-tracking in biopsy-confirmed CA patients (including subtypes), CTRL, HCM, and TR patients.
  • Comparison of strain parameters between groups.
  • Post hoc analysis to identify intergroup differences and assess diagnostic performance (AUC).

Main Results:

  • Significant differentiation (p < 0.001) in reservoir, conduit, and booster RAS and RASRs was observed between CA and HCM, and between CA and CTRL.
  • Booster and reservoir RAS and RASRs demonstrated reliable diagnostic performance (AUC > 0.8).
  • CA patients with AF showed significantly impaired reservoir and booster RAS/RASR compared to those in sinus rhythm. Discriminative power for CA vs. TR was insufficient (p = 0.069). Differentiation between CA subtypes was not achievable.

Conclusions:

  • MRI-derived RAS and RASR are impaired in CA patients.
  • These parameters may support noninvasive differentiation between CA, HCM, and CTRL.
  • Atrial function assessment via RAS/RASR in CA is affected by atrial fibrillation.

Keywords:
cardiac amyloidosiscardiac magnetic resonance imagingcardiac strainright atrium

More Related Videos

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.4K
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
17
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
41
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
29
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
43
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
31
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
20