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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

23
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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lncRNA - Long Non-coding RNAs02:39

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Heart Failure I: Introduction01:27

Heart Failure I: Introduction

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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Comparative Analysis of Non-Coding RNA Transcriptomics in Heart Failure.

Carlos Garcia-Padilla1,2, Estefanía Lozano-Velasco1,2,3, Virginio Garcia-Lopez1

  • 1Department of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain.

Biomedicines
|December 23, 2022
PubMed
Summary

Non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs show promise as heart failure biomarkers. Standardization of research methods is crucial for their clinical application in managing heart failure.

Keywords:
circular RNAheart failurelong non-coding RNAmicroRNAnon-coding RNAtranscriptomics

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Area of Science:

  • Biomolecular Sciences
  • Cardiovascular Research
  • Genomics

Background:

  • Heart failure is a complex syndrome with increasing prevalence, posing a significant public health challenge.
  • Cardiac homeostasis relies on strict gene expression, making molecular biomarkers essential for improving heart failure management.
  • Non-coding RNA transcriptomics in human samples are increasingly studied for potential diagnostic and prognostic applications.

Purpose of the Study:

  • To conduct a comparative study on the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers for heart failure.
  • To highlight the significance of non-coding RNAs in understanding and managing heart failure.
  • To identify areas for improvement in research methodologies for biomarker discovery.

Main Methods:

  • Comparative analysis of existing literature on non-coding RNA transcriptomics in heart failure.
  • Focus on microRNAs, long non-coding RNAs, and circular RNAs.
  • Review of methodologies used in current research.

Main Results:

  • Non-coding RNAs (microRNAs, long non-coding RNAs, circular RNAs) are relevant potential biomarkers for heart failure.
  • Current research highlights the role of these molecules in cardiac homeostasis.
  • Significant variations in methodologies necessitate standardization for clinical translation.

Conclusions:

  • Further research is fundamental to support the widespread clinical use of non-coding RNA biomarkers in heart failure.
  • Standardization of methodologies, including larger cohorts, sample homogeneity, and uniform bioinformatic pipelines, is essential.
  • These adjustments can lead to novel strategies for the clinical management of heart failure patients.