Glial Contributions to Lafora Disease: A Systematic Review

Area of Science:

• Neuroscience
• Cell Biology
• Pathology

Background:

• Lafora disease (LD) is a fatal neurodegenerative disorder.
• Characterized by polyglucosan body (PB) accumulation in the brain.
• Neuroinflammation is a key feature of LD.

Purpose of the Study:

• Investigate the role of astrocytes and microglia in Lafora disease.
• Systematically review the literature on glial cells in LD.
• Explore potential therapeutic targets in LD.

Main Methods:

• Systematic review adhering to PRISMA guidelines.
• Searches conducted in PubMed, Scopus, and Web-of-Science.
• Independent review by two researchers.

Main Results:

• 35 studies were included in the review.
• Evidence suggests glial cells (astrocytes and microglia) accumulate PBs in LD.
• Glial cells contribute to neurodegeneration and epilepsy in LD.

Conclusions:

• Glial cells are implicated in Lafora disease pathogenesis.
• Targeting glial cells offers potential therapeutic avenues for LD.
• Therapeutic responses may vary due to diverse glial cell phenotypes.