Related Experiment Video
Updated: Aug 16, 2025
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
2.1K
Neurogenic Lower Urinary Tract Dysfunction in Asymptomatic Patients with Multiple Sclerosis.
Anke K Jaekel1,2, Franziska I Winterhagen1,3, Federico L Zeller2
1Department for Neuro-Urology, Clinic for Urology, University Hospital Bonn, 53127 Bonn, Germany.
Biomedicines
|December 23, 2022
Summary
Asymptomatic patients with multiple sclerosis (MS) often have neurogenic lower urinary tract dysfunction (NLUTD). Early screening for NLUTD is recommended in all MS patients, irrespective of symptoms or disease stage.
Area of Science:
- Neurology
- Urology
- Neuro-urology
Background:
- Neurogenic lower urinary tract dysfunction (NLUTD) is a known complication of multiple sclerosis (MS).
- Current clinical practice often delays neuro-urological diagnostics until urinary symptoms manifest.
- Limited research exists on NLUTD in asymptomatic MS patients.
Purpose of the Study:
- To characterize NLUTD in asymptomatic MS patients.
- To identify correlations between clinical parameters and NLUTD in this population.
- To evaluate the necessity of screening for NLUTD regardless of symptoms.
Main Methods:
- Evaluation of bladder diaries, urodynamic findings, and uroflowmetry with post-void residual.
- Correlation analysis of voided volume, voiding frequency, UTIs, and uroflowmetry with urodynamic results.
- Assessment of asymptomatic MS patients.
Main Results:
- 26% of MS patients studied were asymptomatic.
- 73.7% of asymptomatic patients showed urodynamic evidence of NLUTD.
- Significant correlations were found between bladder diary parameters, UTIs, and NLUTD.
Conclusions:
- Asymptomatic status does not rule out NLUTD in MS patients.
- Urinary tract damage can be present early in MS, even without symptoms.
- Routine screening for NLUTD is recommended for all MS patients, irrespective of symptoms or disease stage.
Related Concept Videos
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
27
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
27
01:26The Micturition Reflex
889
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
889
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
170
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
170
01:21Nursing Assessment of the Genitourinary System I: Health History
64
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
64
01:23Urinary Bladder
1.2K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
1.2K
01:17Urinary Tract Infection IV: Nursing Management
65
In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
65