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Related Experiment Video

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Anodal-TDCS over Left-DLPFC Modulates Motor Cortex Excitability in Chronic Lower Back Pain.

Emily J Corti1,2, An T Nguyen1,2, Welber Marinovic1,2

  • 1School of Population Health, Curtin University, GPO Box U1987, Bentley, WA 6102, Australia.

Brain Sciences
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

Anodal transcranial direct current stimulation (tDCS) over the left-dorsolateral prefrontal cortex (left-DLPFC) showed potential in reducing pain and disability for chronic lower back pain (CLBP) patients. This intervention modulated cortical excitability, offering preliminary support for its therapeutic use.

Keywords:
chronic lower back painexcitabilitymotor cortextranscranial direct current stimulationtranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Pain Management
  • Neuromodulation

Background:

  • Chronic lower back pain (CLBP) is linked to altered cortical excitability and heightened pain perception.
  • Transcranial direct current stimulation (tDCS) research for CLBP shows inconsistent outcomes regarding motor cortex modulation and pain reduction.

Purpose of the Study:

  • To investigate the effect of anodal tDCS on the left-dorsolateral prefrontal cortex (left-DLPFC) on motor cortex excitability and pain in individuals with CLBP.
  • To assess changes in short interval intracortical inhibition (SICI) and intracortical facilitation (ICF) following tDCS intervention.

Main Methods:

  • A randomized, placebo-controlled study involving 19 participants with CLBP.
  • Participants received 20-minute sessions of either sham or anodal tDCS, twice weekly for 4 weeks.
  • Motor cortex excitability was measured using paired-pulse Transcranial Magnetic Stimulation (TMS) to assess SICI and ICF before and after the intervention.

Main Results:

  • While initial analyses showed no significant group or time effects on SICI or ICF, Bayesian analyses indicated increased ICF and SICI in the anodal-tDCS group post-intervention.
  • The anodal-tDCS group reported significant reductions in pain intensity and self-reported disability compared to the sham-tDCS group.

Conclusions:

  • Anodal tDCS applied to the left-DLPFC demonstrates preliminary efficacy in modulating cortical excitability.
  • This neuromodulation technique shows potential for reducing pain and disability in individuals suffering from chronic lower back pain (CLBP).