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Upper extremity injuries due to medications.

A E Seyfer1

  • 1Division of Plastic and Reconstructive Surgery, Uniformed Services University of the Health Sciences.

The Journal of Hand Surgery
|September 1, 1987
PubMed
Summary

Therapeutic agents can cause upper extremity injuries, with chemotherapy and "non-toxic" solutions leading to complications. Effective management involves stopping the IV, elevation, avoiding antidotes, delayed surgery, and early rehabilitation.

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Area of Science:

  • Medical Science
  • Surgical Complications
  • Pharmacology

Background:

  • Upper extremity complications can arise from therapeutic agents.
  • Injuries are associated with both chemotherapy and "non-toxic" solutions.

Purpose of the Study:

  • To analyze upper extremity complications from therapeutic agents.
  • To identify effective management strategies for these complications.

Main Methods:

  • Retrospective analysis of 111 patients treated for upper extremity complications.
  • Categorization of injuries based on the type of therapeutic agent (chemotherapy vs. "non-toxic" solutions).
  • Review of surgical interventions (debridement, fasciotomies) and conservative management.

Main Results:

  • 49 injuries linked to chemotherapy, 62 to "non-toxic" solutions.
  • 25 patients required debridement and skin coverage.
  • 6 patients underwent emergency fasciotomies.

Conclusions:

  • Immediate cessation of the intravenous line is crucial.
  • Elevation and avoidance of antidotes are recommended.
  • Late debridement and coverage, coupled with early rehabilitation, represent the most effective management regimen.

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