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Association between Thyroid Function and Ocular Parameters.

Mirjana Babić Leko1, Nikolina Pleić1, Mladen Lešin2

  • 1Department of Medical Biology, School of Medicine, University of Split, 21000 Split, Croatia.

Biology
|December 23, 2022
PubMed
Summary
This summary is machine-generated.

Thyroid hormones impact eye health. This study found thyroid activity influences ocular parameters like corneal thickness and anterior chamber angle in healthy adults, suggesting a link between thyroid status and eye measurements.

Keywords:
TSHanterior chamber anglecorneal thicknesshyperthyroidismhypothyroidismintraocular lens powerocular parametersspherical powerthyroid hormones

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Area of Science:

  • Ophthalmology and Endocrinology
  • Thyroid function and ocular health

Background:

  • Thyroid hormones are crucial for eye development and function.
  • Pathological thyroid conditions can adversely affect ocular health.
  • Limited research exists on the association between ocular parameters and thyroid function.

Purpose of the Study:

  • To investigate the relationship between thyroid activity and various ocular parameters in healthy adults.
  • To determine if thyroid status influences measurements such as corneal thickness, intraocular lens power, and anterior chamber angle.

Main Methods:

  • Cross-sectional study of 4633 healthy adults from the 10,001 Dalmatians project.
  • Measurement of plasma thyroid hormones: TSH, fT3, fT4, Tg, TgAb, TPOAb.
  • Determination of 20 ocular parameters per participant, including corneal thickness, anterior chamber angle, and axial length.

Main Results:

  • Hyperthyroid patients exhibited thicker corneas than euthyroid individuals.
  • Corneal thickness showed a negative association with TSH levels.
  • Intraocular lens power was higher in hypothyroidism, and spherical power varied with antibody presence and thyroid hormone levels.

Conclusions:

  • Thyroid activity is associated with specific ocular parameters, including corneal thickness and anterior chamber angle.
  • These findings highlight an interplay between ophthalmic measures and thyroid status, observable in the general adult population.