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Updated: Jun 25, 2026

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage
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Oxidative Stress and Intracranial Hypertension after Aneurysmal Subarachnoid Hemorrhage

Guangshan Hao1,2, Pinar Eser3, Jun Mo1,4

  • 1Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.

Antioxidants (Basel, Switzerland)
|December 23, 2022
PubMed

Intracranial hypertension is a common phenomenon in patients with aneurysmal subarachnoid hemorrhage (aSAH). Elevated intracranial pressure (ICP) plays an important role in early brain injuries and is associated with unfavorable outcomes. Despite advances in the management of aSAH, there is no consensus about the mechanisms involved in ICP increases after aSAH. Recently, a growing body of evidence suggests that oxidative stress (OS) may play a crucial role in physio-pathological changes following aSAH, which may also contribute to increased ICP. Herein, we discuss a potential relation between increased ICP and OS, and resultantly propose antioxidant mechanisms as a potential therapeutic strategy for the treatment of ICP elevation following aSAH.

Keywords:
antioxidantbrain injuryintracranial hypertensionoxidative stresssubarachnoid hemorrhage

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