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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Thrombosis in Chronic Kidney Disease in Children

Tudor Ilie Lazaruc1, Lavinia Bodescu Amancei Ionescu1, Vasile Valeriu Lupu1

  • 1Department of Pediatrics, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

Diagnostics (Basel, Switzerland)
|December 23, 2022
PubMed

Insights

Pediatric venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is rising due to medical advancements. This review covers VTE causes, diagnosis, and treatment in children, particularly those with chronic kidney disease.

Area of Science:

  • Pediatric Hematology
  • Nephrology
  • Cardiology

Background:

  • Pediatric venous thromboembolism (VTE) is increasingly recognized.
  • Factors contributing to this rise include improved survival in chronic conditions like chronic kidney disease (CKD), increased catheter use, and enhanced diagnostic sensitivity.
  • VTE in children carries significant risks, including higher mortality and post-thrombotic syndrome.

Purpose of the Study:

  • To provide a state-of-the-art overview of pediatric thrombosis.
  • To review the physiologic and pathologic mechanisms underlying VTE in children.
  • To update current diagnostic and treatment strategies for pediatric VTE, with an emphasis on CKD patients.

Main Methods:

  • Literature review of pediatric thrombosis.
  • Analysis of VTE prevalence and risk factors in specific pediatric populations.
  • Discussion of diagnostic and therapeutic approaches.

Main Results:

  • VTE is associated with a 2-6 times higher mortality risk in children.
  • Approximately 5% of pediatric VTE cases are linked to chronic kidney disease (CKD).
  • VTE incidence is 3% in children with nephrotic syndrome (NS), with heightened risk in the first 6 months post-onset.

Conclusions:

  • VTE in children, especially those with CKD, requires careful management due to associated risks.
  • Understanding the underlying mechanisms and updated diagnostic/treatment options is crucial for improving outcomes.
  • Further research and personalized approaches are needed for effective VTE prevention and treatment in pediatric populations.

Keywords:
childchronic kidney diseasevenous thromboembolism

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