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Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with

Violeta Diana Oprea1,2, Mihai Marinescu1,2, Corina Rișcă Popazu1,2

  • 1Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 800216 Galați, Romania.

Diagnostics (Basel, Switzerland)
|December 23, 2022
PubMed

Insights

Cognitive impairment in older adults is linked to cardiovascular, metabolic, and neurologic conditions. Serum vitamin D levels correlate with cognitive and functional status, suggesting potential early diagnostic markers for dementia.

Area of Science:

  • Neurology
  • Geriatrics
  • Internal Medicine

Background:

  • Dementia is an incurable, multifactorial neurodegenerative disease.
  • Early diagnosis and accurate prognosis are crucial for managing cognitive impairment.
  • Patient characteristics require analysis to identify potential correlations.

Purpose of the Study:

  • To analyze patient characteristics for correlations supporting early dementia diagnosis.
  • To assess links between cognitive impairment and various comorbidities.
  • To investigate the relationship between cognitive status, functional status, and vitamin D levels.

Main Methods:

  • Studied 162 patients aged over 55 years.
  • Utilized standard clinical parameters: cognitive and functional status, comorbidities, and plasma vitamin D levels.
  • Performed correlation analysis on gathered patient data.

Main Results:

  • Higher incidence of cardiovascular and metabolic comorbidities in patients with moderate to severe cognitive impairment.
  • Validated correlation found between functional status, cognitive status, and serum vitamin D levels.
  • Neurologic comorbidities were more frequently associated with significant cognitive deficiency.

Conclusions:

  • Cognitive deficits significantly correlate with cardiovascular, metabolic, and neurologic diseases.
  • No significant correlation was found with osteoarticular illness.
  • Clinical tools for screening and assessment, including risk factor evaluation, are vital for managing cognitive impairment and dementia.

Keywords:
cardiovascular riskcognitive declinedementiadepressionfunctional statusvitamin D deficiency

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