Systemic Lymphadenopathic Mastocytosis with Eosinophilia

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Systemic mastocytosis involves neoplastic mast cell proliferation, typically affecting skin.
• Extracutaneous involvement is known, but lymph node presentation is infrequent.

Purpose of the Study:

• To report a rare case of systemic mastocytosis involving the lymph node.
• To highlight the diagnostic challenges and features of this rare subtype.

Main Methods:

• Case presentation with histopathological examination of lymph node biopsy.
• Review of relevant literature on systemic mastocytosis and lymph node involvement.

Main Results:

• Demonstration of systemic mastocytosis in the lymph node.
• Significant eosinophilia observed in the affected lymph node.
• The case represents a rare subtype of systemic mastocytosis.

Conclusions:

• Systemic mastocytosis can manifest rarely in lymph nodes.
• Marked eosinophilia in lymph node mastocytosis suggests a specific subtype.
• High clinical and pathological suspicion is crucial for diagnosing this rare condition.