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Exploratory Expression Analysis of Stem Cell and Epithelial-Mesenchymal Transition Markers in Ameloblastoma.

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Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis.

Emiliano Jurado-Castañeda1, Carla Monserrat Ramírez-Martínez1, Alejandro Alonso-Moctezuma2

  • 1Department of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City 04510, Mexico.

Diagnostics (Basel, Switzerland)
|December 23, 2022
PubMed
Summary

Ameloblastoma, a rare benign tumor, can be locally aggressive and recur. This study identified eight key genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, APOA2) involved in ameloblastoma pathogenesis.

Keywords:
ameloblastomabioinformaticshemimandibulectomymicroarray analysisodontogenic tumor

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Oncology
  • Genetics

Background:

  • Ameloblastoma is a rare, benign epithelial odontogenic neoplasm.
  • Despite its benign nature, it exhibits local aggressiveness and a high recurrence rate.
  • Understanding its complex pathogenesis is crucial for effective management.

Observation:

  • A case study of a 20-year-old patient with a clinical and radiographic diagnosis of ameloblastoma.
  • Incisional biopsy confirmed conventional ameloblastoma.
  • Surgical resection involved left hemimandibulectomy and plate reconstruction.

Findings:

  • Histopathological analysis revealed conventional ameloblastoma with a plexiform pattern, cystic degeneration, and amyloid-like deposits.
  • Microarray and bioinformatic analysis identified eight hub genes (CRP, BCHE, APP, AKT1, AGT, ACTC1, ADAM10, APOA2) linked to ameloblastoma pathogenesis.
  • These genes are implicated in pathways related to tumor growth and progression.

Implications:

  • The identification of specific hub genes provides potential molecular targets for future therapeutic strategies.
  • This research contributes to a deeper understanding of ameloblastoma's complex biological behavior.
  • Further investigation into these genes may lead to improved diagnostic and prognostic tools for ameloblastoma.