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Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!
1Division of Neonatology, Department of Pediatrics, John R Oishei Children's Hospital, University at Buffalo, 1001 5th Floor Main Street, Buffalo, NY 14203, USA.
Insights
Adults born preterm face higher risks of serious cardiometabolic disorders, including hypertension and diabetes. Early recognition and lifelong monitoring are crucial for improving their long-term health and quality of life.
Area of Science:
- Neonatology
- Cardiology
- Metabolic Health
Background:
- Improved survival rates for preterm infants necessitate a focus on their long-term health into adulthood.
- Preterm birth is increasingly linked to adverse cardiometabolic outcomes in adulthood.
- Adults born preterm exhibit a higher risk of conditions like hypertension, type 2 diabetes, and heart disease.
Purpose of the Study:
- To highlight the significant cardiometabolic risks faced by adults born preterm.
- To emphasize the need for specialized healthcare approaches for this unique population.
- To advocate for improved long-term monitoring and interventions for preterm survivors.
Main Methods:
- Review of epidemiological evidence linking preterm birth to adult cardiometabolic diseases.
- Analysis of the interconnectedness of cardio-pulmonary systems in preterm survivors.
- Identification of challenges in current healthcare for adults born preterm.
Main Results:
- Adults born preterm have a demonstrably higher risk of developing cardiometabolic disorders compared to full-term peers.
- The interconnected cardio-pulmonary system can lead to increased morbidity and mortality in this population.
- Current healthcare systems face challenges in recognizing and addressing the specific needs of adults born preterm.
Conclusions:
- Holistic management is essential to promote cardiovascular health and improve quality of life for adults born preterm.
- Technological advancements for physiological assessment and early screening tools are vital.
- Robust, longitudinal follow-up is critical for enhancing both longevity and well-being in adults born preterm.
Abstract:
Advances in perinatal and neonatal care have led to improved survival of preterm infants into adulthood. However, the shift in focus to long-term health in adults born preterm requires a clear understanding of the impact of prematurity on developing organ systems and the development of adult-oriented disease. A less well-recognized area of risk for surviving preterm infants is their cardiometabolic health. Epidemiologic evidence has linked preterm birth to the development of systemic hypertension, type 2 diabetes, metabolic syndrome, heart failure, and ischemic heart disease. Of more significant concern is that the risk of cardiometabolic disorders is higher in adults born preterm compared to full-term infants. The interconnected nature of the cardio-pulmonary system means worsening morbidity and mortality in adults born preterm. Addressing the problems of adults born preterm holistically would help promote cardiovascular health, wellness, and quality of life over their lifetime. Recognizing that adults born preterm are a unique subset of the population is a challenge in the current healthcare environment. Addressing issues relevant to adults born preterm in the clinically and research domain, using technology to characterize cardiopulmonary physiology and exercise tolerance, developing screening tools for early diagnosis and treatment, and robust follow-up of these infants with access to longitudinal data would improve both the quality and longevity of life in adults born preterm.
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