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Tonsillectomy in Children with 22q11.2 Deletion Syndrome
Jill M Arganbright1,2, Paul Bryan Hankey3, Meghan Tracy1
1Division of Otolaryngology, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA.
Genes
|December 23, 2022
Summary
Tonsillectomy is common in children with 22q11.2 deletion syndrome (22q11DS) for speech and sleep issues. Post-surgery, persistent sleep apnea and complications like hypocalcemia require monitoring.
Area of Science:
- Pediatric Otolaryngology
- Genetics
- Sleep Medicine
Background:
- Tonsillectomy is a frequent pediatric surgery.
- No prior studies evaluated tonsillectomy in 22q11.2 deletion syndrome (22q11DS).
Purpose of the Study:
- Investigate indications, efficacy, and complications of tonsillectomy in pediatric 22q11DS patients.
- Characterize surgical outcomes and identify potential risks.
Main Methods:
- Retrospective chart review of 33 pediatric patients with 22q11DS and tonsillectomy history.
- Data included indications, polysomnography (PSG) results, and surgical complications.
Main Results:
- Common indications: speech surgery facilitation (21 patients) and sleep-disordered breathing/obstructive sleep apnea (OSA) (16 patients).
- 18% of patients experienced complications (respiratory distress, hemorrhage, hypocalcemia).
- 69% had persistent OSA post-surgery, indicating limited PSG efficacy.
Conclusions:
- Tonsillectomy is frequently performed in pediatric 22q11DS patients.
- Close postoperative monitoring for calcium and respiratory issues is crucial.
- Further research is needed to fully understand OSA outcomes and complications in this population.
Keywords:
22q11.2 deletion syndromeadenotonsillectomycomplicationsobstructive sleep apneatonsillectomyMore Related Videos
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