Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Drift03:33

Genetic Drift

40.4K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
40.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.9K
Frequency-dependent Selection01:21

Frequency-dependent Selection

22.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.2K
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.8K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.8K
Quantifying and Rejecting Outliers: The Grubbs Test01:02

Quantifying and Rejecting Outliers: The Grubbs Test

1.8K
Sometimes, a data set can have a recorded numerical observation that greatly  deviates from the rest of the data. Assuming that the data is normally distributed, a statistical method called the Grubbs test can be used to determine whether the observation is truly an outlier.  To perform a two-tailed Grubbs test, first, calculate the absolute difference between the outlier and the mean. Then, calculate the ratio between this difference and the standard deviation of the sample. This...
1.8K
Genetic Variation01:25

Genetic Variation

353
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
353

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions.

Cell cycle (Georgetown, Tex.)·2011
Same author

Globular adiponectin protects human umbilical vein endothelial cells against apoptosis through adiponectin receptor 1/adenosine monophosphate-activated protein kinase pathway.

Chinese medical journal·2011
Same author

Single-side organically functionalized Anderson-type polyoxometalates.

Chemistry (Weinheim an der Bergstrasse, Germany)·2011
Same author

Buildup of amphiphilic molecular bola from organic-inorganic hybrid polyoxometalates and their vesicle-like supramolecular assembly.

Chemistry (Weinheim an der Bergstrasse, Germany)·2011
Same author

Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart.

Science translational medicine·2011
Same author

The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: surveillance data from 2006 to 2010.

PloS one·2011

Related Experiment Video

Updated: Aug 16, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.4K

An Improved Bayesian Shrinkage Regression Algorithm for Genomic Selection.

Jin Zhang1, Ling Li1,2, Mingming Lv1

  • 1College of Science, Nanjing Agricultural University, Nanjing 210095, China.

Genes
|December 23, 2022
PubMed
Summary

A new algorithm, emBAI, improves genomic selection (GS) by enhancing genomic estimated breeding value (GEBV) prediction accuracy. This method offers better performance in animal and plant breeding, accelerating genetic progress.

Keywords:
BayesianGEBVgenomic selectionmixed linear modelpolygenic background

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.6K
Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

18.4K

Related Experiment Videos

Last Updated: Aug 16, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.4K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.6K
Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

18.4K

Area of Science:

  • Genomics
  • Quantitative Genetics
  • Bioinformatics

Background:

  • Genomic selection (GS) accelerates breeding progress by estimating breeding values using all available SNPs.
  • Accurate genomic estimated breeding values (GEBV) are crucial for effective GS.
  • Existing algorithms can be improved, especially in the context of big data.

Purpose of the Study:

  • To develop a novel algorithm, emBAI (expectation-maximization Bayesian Shrinkage Regression), to enhance GEBV prediction accuracy.
  • To validate the emBAI algorithm using simulation experiments and a real dataset.
  • To assess the performance of emBAI in terms of prediction accuracy, error metrics, and loci detection.

Main Methods:

  • Developed the emBAI algorithm within the Bayesian Shrinkage Regression (BSR) framework.
  • Implemented an improved expectation-maximization algorithm for BayesA (emBayesA).
  • Validated emBAI using two simulation experiments and an Arabidopsis flowering time dataset.

Main Results:

  • emBAI demonstrated superior prediction accuracy, lower MSE and MAE, and higher AUC and correlation compared to established methods in simulations.
  • The algorithm performed well with increasing genetic background.
  • Real data analysis confirmed emBAI's benefits for genomic prediction and identified significant loci.

Conclusions:

  • The emBAI algorithm offers a powerful approach to improve genomic selection in high-dimensional genomic datasets.
  • emBAI enhances GEBV accuracy, aiding breeders in animal and plant improvement.
  • The method also improves significant loci detection and effect coefficient estimation.