[Peptidyltransferase center of ribosomes. Structure and relationship to other ribosomal functions]

Structural analysis of the ribosomal peptidyl transferase center using model substrates "minimal" peptide acceptors and donors is reported in the present work. Recent data on the ribosomal proteins and rRNA organizing the peptidyl transferase center and other functional centers of the large ribosomal subunits are given and the know facts about the catalytic mechanism of the peptide bond formation are considered. An analysis of the interaction of the peptidyl transferase center and the centers binding the cytoplasmic translocation factors and stringent-factor (for E. coli ribosome) is presented; a possible contribution of the peptidyl transferase center ot the translocation is discussed.